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Form   8820                                          Orphan Drug Credit                                         OMB No. 1545-1505

(Rev. September 2017)       ▶ Go to www.irs.gov/Form8820 for the latest information.                            Attachment   
Department of the Treasury                            ▶ Attach to your tax return.                              Sequence No. 103
Internal Revenue Service 
Name(s) shown on return                                                                                      Identifying number

Part I Current Year Credit

1      Qualified clinical testing expenses paid or incurred during the tax year (see instructions) . . . .   1 

2a     Current year credit. Multiply line 1 by 50% (0.50). See instructions  . . . .     . . . .     . . .   2a 

b      Enter the portion of the credit from Form 8932, line 2, that is attributable to wages that were also 
       used to figure the credit on line 2a above  .  . . . .       . . . .    . . .     . . . .     . . .   2b

c      Subtract line 2b from line 2a. If zero or less, enter -0-  . . . . .    . . .     . . . .     . . .   2c 

3      Orphan drug credit from partnerships, S corporations, estates, or trusts  . .     . . . .     . . .   3 

4      Add lines 2c and 3. Estates and trusts go to line 5. Partnerships and S corporations, report this 
       amount on Schedule K. All others, report this amount on Form 3800, Part III, line 1h  . .     . . .   4 

5      Amount allocated to the beneficiaries of the estate or trust (see instructions) . . . . .     . . .   5 

6      Estates and trusts. Subtract line 5 from line 4. Report this amount on Form 3800, Part III, line 1h . 6 
For Paperwork Reduction Act Notice, see instructions.                     Cat. No. 11208S                       Form 8820 (Rev. 9-2017)



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Form 8820 (Rev. 9-2017)                                                                     Page 2
Part II   Orphan Drug Information (see instructions)
                                                                                        (d) 
(a)                     (b)                         (c)                            Date drug designated 
                        Name of orphan drug         Designation application number      (mm/dd/yyyy)
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k

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                                                                                   Form 8820 (Rev. 9-2017)



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Form 8820 (Rev. 9-2017)                                                                                             Page 3

General Instructions                         2. The testing occurs after the      Member of Controlled Group 
                                          date the drug is designated under 
Section references are to the Internal                                            or Business Under Common 
                                          Act section 526 and before the date 
Revenue Code unless otherwise                                                     Control
                                          on which an application for the drug 
noted.                                                                            For purposes of figuring the credit, 
                                          is approved under Act section 505(b) 
Future developments. For the latest       (or, if the drug is a biological        all members of a controlled group of 
information about developments            product, before the date the drug is    corporations (as defined in section 
related to Form 8820 and its              licensed under section 351 of the       41(f)(1)(A) and (f)(5)) and all members 
instructions, such as legislation         Public Health Service Act).             of a group of businesses under 
enacted after this form and                                                       common control (as defined in 
                                             3. The testing is conducted by or 
instructions were published, go to                                                section 41(f)(1)(B)), are treated as a 
                                          for the taxpayer to whom the 
www.irs.gov/Form8820.                                                             single taxpayer. As a member, your 
                                          designation under Act section 526 
Purpose of Form                           applies.                                credit is determined on a 
                                                                                  proportionate basis to your share of 
Use Form 8820 to claim the orphan            4. The testing relates to the use of the aggregate clinical testing 
drug credit. The credit is 50% of         the drug for the rare disease or        expenses taken into account by the 
qualified clinical testing expenses       condition for which it was              group for the orphan drug credit. 
paid or incurred during the tax year.     designated under Act section 526.       Enter your share of the credit on line 
See section 45C and Regulations           Rare disease or condition. A rare       2a. Attach a statement showing how 
section 1.28-1 for details.               disease or condition is one which       your share of the credit was figured, 
Taxpayers that are not                    afflicts:                               and write “See Attached” next to the 
partnerships, S corporations,             • 200,000 or fewer persons in the       entry space for line 2a.
estates, or trusts, and whose only        United States or
source of this credit is from those       • More than 200,000 persons in the      Specific Instructions
pass-through entities, are not            United States, but for which there is   Figure any orphan drug credit from 
required to complete or file this form.   no reasonable expectation of            your own trade or business on lines 
Instead, they can report this credit      recovering the cost of developing       1 and 2a.
directly on Form 3800.                    and making available a drug in the      Line 1
Definitions                               United States for the disease from      Complete Part II for each orphan 
Qualified clinical testing expenses.      sales of the drug in the United         drug for which qualified clinical 
Generally, qualified clinical testing     States.                                 testing expenses are paid or 
expenses are amounts paid or                 The above determinations are         incurred during the tax year and 
incurred by the taxpayer that would       made as of the date the drug is         included in line 1.
be described as qualified research        designated under Act section 526.
                                                                                  Line 2a
expenses under section 41, with two       Testing Not Eligible for the            Reduce the deduction for qualified 
modifications:
                                          Credit                                  clinical testing expenses otherwise 
• In sections 41(b)(2) and (3), “clinical                                         allowable on your income tax return 
                                          The credit is not allowed for clinical 
testing” is substituted for “qualified                                            by the amount of the credit shown 
                                          testing conducted outside the 
research” and                                                                     on line 2a. If the credit exceeds the 
                                          United States unless there is an 
• 100% (instead of 65% or 75%) of         insufficient U.S. testing population    amount allowed as a deduction for 
contract research expenses are            and the testing is conducted by a       the tax year, reduce the amount 
treated as clinical testing expenses.     U.S. person or by another person        chargeable to the capital account for 
Qualified clinical testing expenses       not related to the taxpayer. Testing    the year for such expenses by the 
do not include expenses to the            conducted either inside or outside      amount of the excess. See section 
extent they are funded by a grant,        the United States by a corporation to   280C(b) for special rules.
contract, or otherwise by a               which section 936 applies is not        Line 2b
governmental entity or another            eligible for the orphan drug credit.    If the credit on line 2a includes 
person.                                                                           wages paid to employees, and you 
                                          Coordination With the 
Clinical testing. Generally, clinical                                             are also claiming a credit for 
testing means any human clinical          Research Credit
                                                                                  employer differential wage payments 
testing that meets all four of the        Qualified clinical testing expenses     based on wages paid to the same 
following conditions.                     used to figure the orphan drug credit   employees, enter on line 2b the 
1. The testing is carried out under       cannot also be used to figure the       portion of the credit from the 
an exemption for a drug being tested      credit for increasing research          employer differential wage credit line 
for a rare disease or condition under     activities. However, any of these       (for example, line 2 of Form 8932) 
section 505(i) of the Federal Food,       expenses that are also qualified        that is attributable to wages that 
Drug, and Cosmetic Act (Act).             research expenses must be included      were also used to figure the credit 
                                          in base period research expenses        on line 2a.
                                          when figuring the credit for 
                                                                                  See Form 8932, Credit for 
                                          increasing research activities in a 
                                                                                  Employer Differential Wage 
                                          later tax year. 
                                                                                  Payments, for information on the 
                                                                                  credit.



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Form 8820 (Rev. 9-2017)                                                                                       Page 4

Line 5                                  Attach as many Part II pages as      The time needed to complete and 
Allocate the orphan drug credit on      needed to show all orphan drugs.     file this form will vary depending on 
line 4 between the estate or trust                                           individual circumstances. The 
and the beneficiaries in the same       Paperwork Reduction Act Notice.      estimated burden for individual and 
                                        We ask for the information on this 
proportion as income was allocated                                           business taxpayers filing this form is 
                                        form to carry out the Internal 
and enter the beneficiaries’ share on                                        approved under OMB control 
                                        Revenue laws of the United States. 
line 5.                                                                      number 1545-0074 and 1545-0123 
                                        You are required to give us the      and is included in the estimates 
If the estate or trust is subject to    information. We need it to ensure    shown in the instructions for their 
the passive activity rules, include on  that you are complying with these    individual and business income tax 
line 3 any orphan drug credit from      laws and to allow us to figure and   return. The estimated burden for all 
passive activities disallowed for prior collect the right amount of tax.     other taxpayers who file this form is 
years and carried forward to this 
                                        You are not required to provide 
year. Complete Form 8582-CR,                                                 shown below.
                                        the information requested on a form 
Passive Activity Credit Limitations,                                         Recordkeeping      . .  1 hr., 54 min.
                                        that is subject to the Paperwork 
to determine the allowed credit that                                         Learning about the 
                                        Reduction Act unless the form 
must be allocated between the                                                law or the form    . . . . .      1 hr.
                                        displays a valid OMB control 
estate or trust and the beneficiaries.                                       Preparing and sending 
                                        number. Books or records relating to 
For details, see the Instructions for                                        the form to the IRS . . 1 hr., 4 min.
                                        a form or its instructions must be 
Form 8582-CR.                                                                If you have comments concerning 
                                        retained as long as their contents 
Part II                                 may become material in the           the accuracy of these time estimates 
                                        administration of any Internal       or suggestions for making this form 
For each drug for which qualified                                            simpler, we would be happy to hear 
                                        Revenue law. Generally, tax returns 
clinical testing expenses are                                                from you. See the instructions for the 
                                        and return information are 
included on line 1, enter the generic                                        tax return with which this form is 
                                        confidential, as required by section 
name of the orphan drug, the                                                 filed.
                                        6103.
Designation application number, and 
the date the drug was designated 
under section 526 of the Federal 
Food, Drug, and Cosmetic Act.






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